Acquired hemophilia A in a patient with advanced prostate cancer

Autopsy And Case Reports

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ISSN: 22361960
Editor Chefe: Maria Claudia Nogueira Zerbini
Início Publicação: 28/02/2011
Periodicidade: Trimestral
Área de Estudo: Medicina

Acquired hemophilia A in a patient with advanced prostate cancer

Ano: 2015 | Volume: 5 | Número: 2
Autores: D. M. Girardi, D. R. A. Silva, P. R. Villaça, C. E. Souza, L. G. Fonseca, D. A. Bastos, P. M. G. Hoff
Autor Correspondente: D. M. Girardi | [email protected]

Palavras-chave: factor 8 deficiency acquired, prostatic neoplasm, hemorrhage

Resumos Cadastrados

Resumo Inglês:

Acquired hemophilia A (AHA) is a rare disorder that results from the presence of autoantibodies against the clotting factor VIII (FVIII) causing hemorrhagic disorders. This entity is mostly associated with autoimmune diseases, pregnancy, the postpartum period, drugs and malignancy. Among the solid cancers, prostate neoplasm is the most common cause of AHA. The management of AHA involves the control of active bleeding and the use of specific therapies to eliminate the inhibitor. The authors describe the case of an 87-year-old man with prostate cancer who developed a bleeding disorder 5 years after the cancer diagnosis. Treatment with prednisone did not reach a satisfactory clinical response, which was only achieved with the association of azathioprine. The patient became asymptomatic with no further bleeding episodes, but developed a fatal sepsis after 3 months of treatment with these immunosuppressive agents.