Alkaloids and Triterpene from Almeidea coerulea (Nees and Mart.) a. St.-Hil. and Anti-leishmanial Activity

Brazilian Archives Of Biology And Technology

Endereço:
Rua Professor Algacyr Munhoz Mader 3775, CIC
Curitiba / PR
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Site: http://www.scielo.br/babt
Telefone: (41) 3316-3012
ISSN: 15168913
Editor Chefe: Carlos Ricardo Soccol
Início Publicação: 30/11/1946
Periodicidade: Bimestral
Área de Estudo: Biologia geral

Alkaloids and Triterpene from Almeidea coerulea (Nees and Mart.) a. St.-Hil. and Anti-leishmanial Activity

Ano: 2011 | Volume: 54 | Número: 1
Autores: Lucia Elaine Ranieri Cortez, Izabel Cristina Piloto Ferreira, Maria Valdrinez Campana Lonardoni, Antonio Gilberto Ferreira, Paulo Cesar Vieira, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes, Diógenes Aparicio Garcia Cortez
Autor Correspondente: Diógenes Aparicio Garcia Cortez | [email protected]

Palavras-chave: almeidea coerulea, rutaceae, indolopyridoquinazoline alkaloid, and anti-leishmanial activity

Resumos Cadastrados

Resumo Inglês:

The dichloromethane extract of Almeidea coerulea stems yielded the (11-hydroxyrutaecarpine alkaloid reported for
the first time from this species) and the triterpene (28-hydroxy-28, 29-dihydrolupeol). The dictamine, skimianine,
sitosterol and stigmasterol were also isolated from methanol extract. Extracellular forms of Leishmania
amazonensis (promastigotes) was tested with dichloromethane extract and 28-hydroxy-28, 29-dihydrolupeol with
showed anti-leishmanial activity above 0.1 mg/mL and 75μg/mL (inhibited 50% promastigote growth), respectively.