Alkaloids and Triterpene from Almeidea coerulea (Nees and Mart.) a. St.-Hil. and Anti-leishmanial Activity

Ano: 2011 | Volume: 54 | Número: 1

Autores: Lucia Elaine Ranieri Cortez, Izabel Cristina Piloto Ferreira, Maria Valdrinez Campana Lonardoni, Antonio Gilberto Ferreira, Paulo Cesar Vieira, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes, Diógenes Aparicio Garcia Cortez

Palavras-chave: almeidea coerulea, rutaceae, indolopyridoquinazoline alkaloid, and anti-leishmanial activity

Resumo Inglês:

The dichloromethane extract of Almeidea coerulea stems yielded the (11-hydroxyrutaecarpine alkaloid reported for
the first time from this species) and the triterpene (28-hydroxy-28, 29-dihydrolupeol). The dictamine, skimianine,
sitosterol and stigmasterol were also isolated from methanol extract. Extracellular forms of Leishmania
amazonensis (promastigotes) was tested with dichloromethane extract and 28-hydroxy-28, 29-dihydrolupeol with
showed anti-leishmanial activity above 0.1 mg/mL and 75μg/mL (inhibited 50% promastigote growth), respectively.