CHAVES, E. A.; PEREIRA-JUNIOR, P. P.; FORTUNATO, R. S.; CARVALHO,
D. P.; NASCIMENTO, J. H. M.; OLIVEIRA, M. F. Cardioproteção induzida pelo
exercÃcio é prejudicada pelo tratamento com o anabolizante decanoato de
nandrolona. Brazilian Journal of Biomotricity. v. 1, n. 3, p. 46-55, 2007. Os
efeitos benéficos do exercÃcio na redução das doenças cardiovasculares já
estão bem descritos na literatura. Dentre as várias adaptações, encontramos a
maior tolerância do tecido cardÃaco a eventos isquêmicos (infartos). Associado
ao exercÃcio encontramos o abuso de anabolizantes, visando ganho de força,
de massa muscular e perda de gordura. Sabe-se que as superdosagens de
anabolizantes levam a danos no sistema cardiovascular, contrapondo-se aos
efeitos benéficos descritos no exercÃcio. Nesse trabalho, mostramos que a
maior tolerância a eventos isquêmicos induzida pelo exercÃcio foi prejudicada
pelo tratamento com decanoato de nandrolona.
CHAVES, E. A.; PEREIRA-JUNIOR, P. P.; FORTUNATO, R. S.; CARVALHO,
D. P.; NASCIMENTO, J. H. M.; OLIVEIRA, M. F. Cardioprotection induced by
exercise is impaired by Nandrolone Decanoate. v. 1, n. 3, p. 46-55, 2007. The
beneficial effects of exercise in reducing the incidence of cardiovascular
diseases are well known and the abuse of anabolic androgenic steroids (AAS)
has been associated to cardiovascular disorders. Previous studies showed that
heart protection to ischemic events would be mediated by increasing the
antioxidant enzyme activities. Here, we investigated the impact of exercise and
high doses of the AAS nandrolone decanoate (DECA), 10 mgkg(-1) body weight
during 8 weeks, in cardiac tolerance to ischemic events as well as on the
activity of antioxidant enzymes in rats. After a global ischemic event, hearts of
control trained (CT) group recovered about 70% of left ventricular developed
pressure, whereas DECA trained (DT), control sedentary (CS) and DECA
sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size
was significantly lower in the CT group compared to animals of the three other
groups. The activities of the antioxidant enzymes superoxide dismutase (SOD),
glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly
higher in CT animals than in the other three groups, whereas catalase activity
was not affected in any group. Together, these results indicate that chronic
treatment with DECA cause an impairment of exercise induction of antioxidant
enzyme activities, leading to a reduced cardioprotection upon ischemic events.
