The aim of this paper is to assess the changes in the foreign policy of Bolivia and Ecuador during the administrations of Evo Morales (2006-2019) and Rafael Correa (2007-2017), taking into account the interaction between domestic and international factors in both countries. Our working hypothesis argues that the reorientation of the foreign policy of these countries was possible due to a connection between alterations observed in the domestic and international spheres starting in the middle of the 2000s. In the internal sphere, the greater political stability resulting from the restructuring of the party system; in the foreign policy environment, an international system more open to the progressive field, allowing a change in the orientation of Bolivian and Ecuadorian foreign policy, based on that moment on the diversification of partnerships with an anti-United States bias.