Maize (Zea mays L.) is a profitable crop for rural producers, but grain yield is still limited by factors such as not choosing a hybrid resistant to major diseases that cause leaf and pre-harvest damage. Thus, this study was developed with the objective of evaluating the agronomic performance; reaction to the attack of brown spot, white spot, and ear rot complex; and the grain health of maize hybrids. A randomized block experimental design was used, with treatments consisting of eight maize hybrids (DKB 390, DKB 230, DKB 177, 30F53, KWS 9110, KWS 9006, KWS 9004, and Supremo) in five replications. The following traits were evaluated: severity (%) of foliar and ear diseases, incidence (%) of grain pathogens, plant and ear height, yield, 100-seed weight, and final stand. There were significant differences among the hybrids for plant height (PH), yield (YD), and 100-seed weight (SW). The most severe leaf damage was caused by Cercospora zeae-maydis and Pantoea ananatis. Fusarium graminearum occurred in 80 % of the grain of the hybrids, except for DKB 390 and KWS 9110. High grain yield and satisfactory levels of disease resistance were found for the hybrids DKB 177 and KWS 9006.