Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

Autopsy And Case Reports

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Início Publicação: 28/02/2011
Periodicidade: Trimestral
Área de Estudo: Medicina

Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

Ano: 2014 | Volume: 4 | Número: 2
Autores: G. Harada, A. Felipe-Silva, J. G. N. Silva
Autor Correspondente: G. Harada | [email protected]

Palavras-chave: lymphoma large B-cell diffuse, stomach neoplasms, lymphoma AIDS-related, acquired immunodeficiency syndrome

Resumos Cadastrados

Resumo Inglês:

HIV infection is known to be associated with the development of a wide range of neoplasia. About 25 to 40% of HIVpositive
patients will present some kind of malignancy in the course of the disease; among them 10% are non-Hodgkin
lymphomas (NHL) and 20% of these are represented by the diffuse large B-cell lymphoma. HIV-positive patients have a
relative risk of 110 times higher to develop neoplasia, than the non-infected population. The gastrointestinal (GI) tract
is the most frequent extranodal site of involvement. However, the primary GI lymphoma is rare. The authors present a
case of a 31-year-old male patient with a 16-year history of HIV infection, who deliberately withdrew the Highly Active
Antiretroviral Therapy (HAART) regimen and was hospitalized because of a respiratory infection. Because of a long-term
complaint of dyspepsia, an upper gastrointestinal endoscopy was performed disclosing a large elevated and ulcerated
gastric lesion, which biopsy revealed a diffuse large B-cell lymphoma. Clinical, imaging and laboratory tests showed an
early stage diagnosis: Lugano stage I. Although not frequent, the authors alert to considering this neoplasia in all HIV-positive
patients with dyspeptic symptoms.