Fibrosarcoma: a challenging diagnosis

Autopsy And Case Reports

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ISSN: 22361960
Editor Chefe: Maria Claudia Nogueira Zerbini
Início Publicação: 28/02/2011
Periodicidade: Trimestral
Área de Estudo: Medicina

Fibrosarcoma: a challenging diagnosis

Ano: 2013 | Volume: 3 | Número: 3
Autores: C. R. Ferreira, L. G. Fonseca, G. H. M. Piotto, F. C. Geyer, P. S. M. Alcântara
Autor Correspondente: C. R. Ferreira | [email protected]

Palavras-chave: fibrosarcoma, MUC4 protein, human, drug therapy, surgical procedures, operative

Resumos Cadastrados

Resumo Inglês:

Fibrosarcoma represent a rare group of soft tissue malignancies derived from fibrous connective tissue and immature proliferating fibroblasts or undifferentiated anaplastic spindle cells. It affects patients in the fourth and fifth decade of life. Fibrosarcomas can be classified in subtypes such as low-grade fibromyxoid sarcoma (LGFMS) and sclerosing epithelioid fibrosarcoma (SEF), and others. Histological features that overlap between types of fibrosarcomas is well known and reported in the literature. We report the case of a 53-yearold patient who presented a tumor in the axillary fossa, which was initially diagnosed as a solitary fibrous tumor. Due to recurrence of the lesion, as well
as the presence of distant metastases, the histological revision considered the diagnosis of breast metaplastic carcinoma, since the tumor expressed the p63 antigen and estrogen and progesterone receptors. Unexpected resistance to chemotherapy motivated the diagnosis re-evaluation, which was due to MUC4 expression and morphological characteristics concluded by a hybrid LGFMSSEF tumor. The authors call attention to the difficult diagnosis in cases of soft tissue tumors. A broad panel of immunohistochemical research is required as the clinical course is essential to the final diagnosis.