The main manifestations of complex regional pain syndrome are intense pain in one extremity, cold and touch hypersensitivity, local swelling, sweating and discoloration, besides difficulty of movements of the affected limb. More commonly develops in upper extremities of females from 50 to 70 years of age. The pathophysiology of this syndrome is multifactorial, and remains not entirely clear. Frequently, it is unrecognized at clinical sceneries and no complimentary exam is enough to establish the diagnosis. The criteria updated in Budapest (2007) yielded higher diagnostic specificity and sensitivity and are internationally recognized and validated to confirm the hypothesis. The case study of an elderly woman is reported with development of this condition after a long course of right carpal tunnel syndrome related to the manual sewing clothing. The objective is to enhance the awareness of healthcare workers about this association.
