OBJECTIVE: To report the imaging features of laryngeal amyloidosis in 2 patients of our institution, with a brief review of the literature. CASE REPORT: There were 2 patients-a 66-year-old woman and a 40-year-old man. One patient underwent CT scanning that revealed a circumferential and homogeneous soft tissue mass with calcified foci in the glottic and supraglottic regions. There was no bone erosion. The other patient was investigated by MRI scanning which showed a circumferential and homogeneous mass in the supraglottic, glottic, and subglottic regions; the lesion was isointense to the surrounding muscles in T1, and hypointense in T2 sequences, with intense gadolinium enhancement. Biopsies were obtained from both patients, and histopathological examination confirmed the diagnosis of amyloidosis. CONCLUSION: Amyloidosis should be considered in the differential diagnosis of a circumferential and homogeneous laryngeal mass that shows calcifications on CT and low signal intensity in T2-weighted MRI images.
