The World Health Organization recognizes Toxoplasmosis as a major foodborne disease worldwide prevalence. The illness is a zoonosis occurring in areas of greater social vulnerability due to a lack of knowledge about the life cycle of the agent, the protozoan Toxoplasma gondii, when it contaminates soil, water, and consequently, food. The present study revision summarized evidence on natural compounds with anti-T. gondii activity, identified gaps, and proposed priorities for research in plant biotechnology, as several plant assays were communicated around the world, reinforcing the activity upon its life cycle. The authors sought to present the importance of Toxoplasmosis from a broad perspective, addressing aspects such as the impact upon host immunity, and the significance of refined studies evaluating natural products that may assist in controlling, or at least reducing, the harmful effects of this important parasitic infection. Besides the plant biotechnological research potential upon life cycle of Toxoplasma gondii. Finally, it was presented a booklet to health promotion through health education.