We read with special interest some novel articles about cysticercosis and COVID-19 co-infections, as well as of neurocysticercosis (NC) affecting the pituitary gland.1-10 NC is the infection of central nervous system and meninges by the larva of Taenia solium, being considered the major parasitosis of the central nervous system and more prevalent among people from countries of Asia, sub-Saharan Africa, and the Latin America.1,5,8,10 One estimates up 10 cases reported of pituitary and hypothalamus NC in literature;7 although isolated pituitary NC be exceeding uncommon, it may constitute a challenging differential diagnosis with benign and malignant sellar or suprasellar lesions as cystic pituitary adenomas, arachnoid cysts, Rathke's cleft cysts, and craniopharyngioma.4-10 Taking as an example the Rathke's cleft cysts, which may be detected in up one third of routine autopsy studies while clinical diagnosis is usually based on incidental imaging findings, one can better understand the differential diagnostic pitfalls with pituitary NC. In regions with well-known elevated prevalence of NC, such as those before mentioned, this real challenge may acquire wider proportions in the field of public health systems.