INTRODUÇÃO: Cardiovascular diseases can be an emerging complication in cystic fibrosis (CF), as the median life expectancy has improved considerably.
OBJETIVO: The objective of this study was to compare vascular, hemodynamic parameters and arterial stiffness in adult CF patients with healthy participants pared by sex and age.
METODOLOGIA: Cross-sectional observational study. The evaluation of cardiovascular parameters was performed non-invasively using Mobil-O-Graph®.
RESULTADOS: 36 individuals with CF and 35 controls were evaluated. The mean arterial pressure (96.71 ± 10.98 versus 88.61 ± 7.40 mmHg, p = 0.0005), cardiac output (4.86 ± 0.57 versus 4.48 ± 0.44 L/min, p = 0.002) and systolic volume (64.30 ± 11.91 versus 49.02 ± 9.31 ml, p < 0.0001) were significantly lower in the CF group. The heart rate was higher in the CF when compared to the control (77.18 ± 10.47 versus 93.56 ± 14.57 bpm, p < 0.0001). The augmentation index (AIx@75) was higher in the CF (29.94 61617; 9.37 versus 16.52 ± 7.179 %, p<0.0001). AIx@75 was useful in discriminating CF (Area under curve was 88.85% for men and 82.29% for women), with the cutoff value of 20.165% for men and 24.665% for women.
CONCLUSÃO: Individuals with CF presented lower blood pressures and changes in cardiac function with lower stroke volume and cardiac output. The AIx@75, an indirect index of arterial stiffness and direct index of left ventricular overload, is increased in this population. The subclinical findings suggest the need for earlier cardiovascular assessment in this population due to increased risks of cardiovascular disease.
