This work aims at synthesizing novel tetrazole derivatives from
phenothiazine. Phenothiazine is first converted into corresponding nitrile by reacting it
with aldehyde, sodium metabisulphite and sodium cyanide. The nitrile on treatment with
NaN3/DMF yielded the tetrazole derivative. In this work two tetrazole derivatives, viz.,
Dimethyl-{4-[phenothiazin-10-yl-(1H-tetrazol-5-yl)methyl]-phenyl}-amine and 10-[(4-
Methoxy-phenyl)-(1H-tetrazole-5-yl)-methyl-10H-phenothiazine were prepared. The
compounds were synthesized in good yields and their structures were confirmed by IR,
1
H-NMR, mass and elemental analysis. The tetrazole compounds were screened for
antimicrobial activity against bacteria and fungi. The results of the study show that the
compounds present good antimicrobial activity.
