Thermodynamics of Molecular Recognitions between Antineoplastic Drug Taxol and Phosphatidylcholine

Brazilian Archives Of Biology And Technology

Endereço:
Rua Professor Algacyr Munhoz Mader 3775, CIC
Curitiba / PR
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Site: http://www.scielo.br/babt
Telefone: (41) 3316-3012
ISSN: 15168913
Editor Chefe: Carlos Ricardo Soccol
Início Publicação: 30/11/1946
Periodicidade: Bimestral
Área de Estudo: Biologia geral

Thermodynamics of Molecular Recognitions between Antineoplastic Drug Taxol and Phosphatidylcholine

Ano: 2010 | Volume: 53 | Número: 6
Autores: Erhan Süleymanoglu
Autor Correspondente: Erhan Süleymanoglu | [email protected]

Palavras-chave: antineoplastic agents, chemotherapy, taxol, phoshatidylcholine, taxol-membrane interactions, membrane fluidity

Resumos Cadastrados

Resumo Inglês:

The aim of this study was to study the basic features of Taxol recognition with phospholipids by applying the
thermodynamic and spectroscopic measurements. The obtained information could be used further for deductions on
its precise cellular and pharmacological mechanisms of action, on improvements of its solubility properties by
phospholipids, as well as for designing the novel lipidic carriers for drug delivery.