This study describes the adoption of innovations supported by ICT and theirs determinants, in three hospitals at the central region of the city of Sao Paulo - Brazil. The qualitative research was based on 11 interviews and analyzed barriers, facilitators, benefits and future challenges of three innovations aspects: Management System of Intensive Therapy Unit, Patient’s Electronic Medical-Card and Surgery Intelligent Room. The verified benefits were: diminishment of diagnostic errors, prescriptions and interventions, and faster patients’ recovery.