A facile microwave assisted one-pot synthesis of novel 1-methylhexahydroquinazolin-5(6H)-ones and bis-1-methylhexahydroquinazolin-5(6H)- ones

Orbital: The Electronic Journal of Chemistry

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ISSN: 19846428
Editor Chefe: Adilson Beatriz
Início Publicação: 28/02/2009
Periodicidade: Trimestral
Área de Estudo: Química

A facile microwave assisted one-pot synthesis of novel 1-methylhexahydroquinazolin-5(6H)-ones and bis-1-methylhexahydroquinazolin-5(6H)- ones

Ano: 2010 | Volume: 2 | Número: 3
Autores: Madhusudhan Saha, Enamul Karima, Philippe Helissey, Jai N. Vishwakarma, Rishanlang Nongkhlaw
Autor Correspondente: Jai N. Vishwakarma | [email protected]

Palavras-chave: hexahydroquinazolin-5(6h)-ones, bis-hexahydroquinazolin-5(6h)-ones, dimedone, enaminone, 1,3-cyclohexanedione

Resumos Cadastrados

Resumo Inglês:

Novel hexahydroquinazolin-5(6H)-ones 3a-j have been synthesized in good
yields by the reaction of enaminones 2a-b with primary amines and formaldehyde under
the influence microwaves. Enaminones 2a-b have also been reacted with diamines and
formaldehyde under similar conditions resulting in hitherto unreported bishexahydroquinazolin-5(6H)-ones 4a-d and 5a-d. The structures of the molecules have
been established with the help of spectral and analytical data.