The aim of this article is to present an observation on the structural phenomena that culminated in socio-spatial and ethnic-racial segregation, which currently occurs in megacities, large cities and global cities in Africa. To this end, a presentation of futuristic issues that cross contemporary African urbanization discussions will be made. Then, historical issues and discourses present in some African countries, which help to explain ethnic, racial, social and spatial aspects perpetuated in urban space, will be addressed. These aspects will include examples from cities in sub- -Saharan African countries, where overpopulation and high foreign investment in the real estate market aggravate the segregationist effects.